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Sökning: LAR1:lu > Ryska

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  • Astermark, Jan, et al. (författare)
  • Arandomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study.
  • 2009
  • Ingår i: Gematologiâ i Transfuziologiâ. - Ministerstvo Zdravookhraneniya. - 0234-5730. ; 54:5, s. 35-35
  • Tidskriftsartikel (refereegranskat)abstract
    • Arandomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study. J. Astermark(1), Sh. M. Donfield(2), D. M. DiMichele(3), A. Gringeri(4), S. A. Gilbert(2), J. Waters(2), E. Berntorp(1), for the FENOC Study Group. Department for Hematology and Coagulation Disorders, Malmo, University Hospital, Malmo, Sweden(1); Department of Biostatistics, Rho, Chapel Hill, NC2; Department of Pediatrics, Weill Medical College, Cornell University, New York, NY3; Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Italy(4). The development of inhibitory antibodies to factor VIII is a serious complication of hemophilia. FEIBA (factor VIII inhibitorbypassing activity), an activated prothrombin complex concentrate (aPCC), and NovoSeven, recombinant factor Vila (rFVIIa), are used as hemostatic bypassing agents in treating patients with inhibitors. The FENOC study was designed to test equivalence of the products in the treatment of ankle, knee, and elbow joint bleeding. A prospective, open-label, randomized, crossover, equivalency design was used. The parameters of interest were the percentage of patients who reported efficacy in response to FEIBA and the percentage that reported efficacy in response to NovoSeven. A difference in these percentages of no more than 15% was determined to be a clinically acceptable magnitude for equivalence of the 2 products. The primary outcome was evaluation 6 hours after treatment. Data for 96 bleeding episodes contributed by 48 participants were analyzed. The criterion for declaring the 2 products equivalent at 6 hours was not met; however, the confidence interval of the difference in percentages of efficacy reported for each product only slightly exceeded the 15% boundary (11.4-15.7%); p = 0.059. FEIBA and NovoSeven appear to exhibit a similar effect on joint bleeds, although the efficacy between products is rated differently by a substantial proportion of patients. This trial was registered at www.clinicaltrials.gov.
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  • Bondarik, Alexander, et al. (författare)
  • An Experience of Elementwise Calibration Methods Without Use of Phase Measurement Apparatus for Multi-Channel PAA Calibration
  • 2005
  • Ingår i: Antennas. - Radiotehnika. - 0320-9601. ; 92:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Some known elementwise methods of PAA calibration are considered, without use of phase meas-urement apparatus. Features of these methods are described for the case of multi-channel phased array antennas (several hundreds or thousands of channels). Calibration algorithm is suggested for this case, it consists of antenna channels grouping, in-group channel calibration and, finally, mutual calibration of groups. A method for initial phase distribution creation is suggested, to ensure proper level of common antenna signal. Calibration procedure for the cases of 192-channel and 3600-channel antennas is described.
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  • Burova, L. A., et al. (författare)
  • Nephritogenic activity of IgA-binding streptococcus pyogenes : An experimental model of IgA glomerulonephritis
  • 2016
  • Ingår i: Medical Immunology (Russia). - Russian Association of Allergologists and Clinical Immunologists, St. Petersburg Regional Branch (SPb RAACI). - 1563-0625. ; 18:3, s. 221-230
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of present study was to arrange an experimental rabbit model for IgA-nephropathy. To this purpose, an approach was attempted which was previously successfully applied in rabbits, aiming for induction of post-streptococcal glomerulonephritis (PSGN). To induce the nephropathy, we used two Streptococcus pyogenes strains of M4 and M60 serotypes which showed differential IgA-binding capacity mediated by the IgAFc microbial receptors. The renal tissue damage was developed in most animals treated with emm60 S. pyogenes characterized by marked IgAFcR expression and higher IgA-binding ability. By means of morphometric analysis. Significant morphological and immunochemical glomerular changes were revealed in 6/10 rabbits, as follows: (i) massive IgA deposition in the mesangial glomerular cells, atrophy of the capillary net, and tissue oedema; (ii) marked C3-complement deposition in proximal and distal tubules; (iii) a significant infiltration of cortical and medullar areas by lymphocytes associated with weak TNFα production. Noteworthy, we did not observe local IgG deposition in any cases, thus allowing to exclude any role of anti-IgG, or other IgG's in evolution of the pathology. Alternatively, the IgA-deposits may occur due to microbial IgA FcR-IgAcontaining cmplexes, as earlier shown by the Swedish scientists. The above tissue changes were completely absent in kidneys of control animals. Taken together, these data suggest that we have developed an experimental model similar to IgA-nephropathy in humans. The results also extend our knowledge on pathogenic effects of the IgA Fc-binding proteins of Streptococcus pyogenes.
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