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Sökning: WFRF:(Fuentes Christian)

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  • Corsonello, Andrea, et al. (författare)
  • Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study a multicenter cohort observational study
  • 2018
  • Ingår i: BMC Nephrology. - BMC. - 1471-2369 .- 1471-2369. ; 19
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Decline of renal function is common in older persons and the prevalence of chronic kidney disease (CKD) is rising with ageing. CKD affects different outcomes relevant to older persons, additionally to morbidity and mortality which makes CKD a relevant health burden in this population. Still, accurate laboratory measurement of kidney function is under debate, since current creatinine-based equations have a certain degree of inaccuracy when used in the older population. The aims of the study are as follows: to assess kidney function in a cohort of 75+ older persons using existing methodologies for CKD screening; to investigate existing and innovative biomarkers of CKD in this cohort, and to align laboratory and biomarker results with medical and functional data obtained from this cohort. The study was registered at ClinicalTrials.gov, identifier NCT02691546, February 25th 2016. Methods/design: An observational, multinational, multicenter, prospective cohort study in community dwelling persons aged 75 years and over, visiting the outpatient clinics of participating institutions. The study will enroll 2450 participants and is carried out in Austria, Germany, Israel, Italy, the Netherlands, Poland and Spain. Participants will undergo clinical and laboratory evaluations at baseline and after 12 and 24 months-follow-up. Clinical evaluation also includes a comprehensive geriatric assessment (CGA). Local laboratory will be used for 'basic' parameters (including serum creatinine and albumin-to-creatinine ratio), whereas biomarker assessment will be conducted centrally. An intermediate telephone follow-up will be carried out at 6 and 18 months. Discussion: Combining the use of CGA and the investigation of novel and existing independent biomarkers within the SCOPE study will help to provide evidence in the development of European guidelines and recommendations in the screening and management of CKD in older people.
  • Fuentes, Christian, et al. (författare)
  • Making a market for alternatives: marketing devices and the qualification of a vegan milk substitute
  • 2017
  • Ingår i: Journal of Marketing Management. - Westburn Publishers. - 1472-1376. ; 33:7-8, s. 529-555
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this paper is to describe, conceptualise and critically discuss how and with what consequences marketing is used to construct a mass market for vegan substitutes. Drawing on the concepts of the marketing device and qualification, it shows how Oatly – a Swedish company making oat-based products – enrols three sets of marketing devices, i.e. digital media, packaging and stores, to simultaneously ‘alternativise’ and ‘convenienise’ its range of vegan products. The result is the material and discursive construction of a range of vegan products that is qualified as different enough from conventional dairy products to be an attractive alternative, but similar enough to fit into existing practices of shopping for food, cooking and eating. By qualifying products along multiple registers, Oatly constructs ‘plastic’ products, which can be consumed, for various reasons, by various groups of consumers thus enacting a multi-niche market for its products.
  • Fuentes, Maria, et al. (författare)
  • Risk Stories In the Media: Food consumption, risk and anxiety
  • 2015
  • Ingår i: Food, Culture and Society: An International Journal of Multidisciplinary Research. - 1552-8014. ; 18:1, s. 71-87
  • Tidskriftsartikel (refereegranskat)abstract
    • Although media-fueled food scares are often described as linked to consumers’ food anxieties, previous studies of food consumption have failed to explore fully how foodscare reports add to consumers’ anxieties. Using a relational theory of risk and a narrative approach, this article highlights how food-scare reports, through various risk accounts, create anxiety-inducing stories where consumers are appointed as handlers of conflicting food risks. Based on material collected from a 2009 Swedish food scare, the article suggests that food-scare reports construct multiple conflicting risks. The analysis also shows that news reports make consumers responsible for handling these risks and, in addition, involve conflicting instructions regarding how consumers should handle the risks described. The article concludes that it is the combination of conflicting risks and conflicting prescriptions for handling those risks that feeds consumers’ anxieties.
  • Klionsky, Daniel J, et al. (författare)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • Ingår i: Autophagy. - Landes Bioscience. - 1554-8635. ; 8:4, s. 445-544
  • Forskningsöversikt (refereegranskat)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
  • Corsonello, Andrea, et al. (författare)
  • Estimated glomerular filtration rate and functional status among older people : A systematic review
  • 2018
  • Ingår i: European journal of internal medicine. - Elsevier. - 0953-6205 .- 1879-0828. ; 56, s. 39-48
  • Forskningsöversikt (övrigt vetenskapligt)abstract
    • Background: The association between chronic kidney disease (CKD) and functional status may change as a function of the equation used to estimate glomerular filtration rate (eGFR). We reviewed the predictive value of different eGFR equations in regard to frailty and disability outcomes. Methods: We searched Pubmed from inception to March 2018 for studies investigating the association between eGFR and self-reported and/or objective measures of frailty or disability. Cross-sectional and longitudinal studies were separately analysed. Results: We included 16 studies, one of which reporting both cross-sectional and longitudinal data. Three out of 7 cross-sectional studies compared different eGFR equations in regard to their association with functional status: two studies showed that cystatin C-based, but not creatinine-based eGFR may be associated with hand-grip strength or frailty; another study showed that two different creatinine-based eGFR equations may be similarly associated with disability. Four out of 10 longitudinal studies provided comparative data: two studies reported similar association with disability for different creatinine-based eGFR equations; one study showed that creatinine-based eGFR was not associated with frailty, but a not significant trend for association was observed with cystatin C-based eGFR; one study showed that cystatin C-based but not creatinine-based eGFR may predict incident mobility disability, while both methods may predict gait speed decline. High heterogeneity was observed in regard to confounders included in reviewed studies. None of them included the most recently published equations. Conclusion: Available data do not support the superiority of one of the eGFR equations in terms of measuring or predicting functional decline.
  • Fredriksson, Cecilia, et al. (författare)
  • Gröna butiker skapar nytt värde
  • 2010
  • Ingår i: Miljöforskning : Formas tidning för ett uthålligt samhälle. - Formas. - 1650-4925. ; :5, s. 26-27
  • Tidskriftsartikel (populärvet., debatt m.m.)
  • Fuentes, Christian, et al. (författare)
  • Agencing ethical consumers: smartphone apps and the socio-material reconfiguration of everyday life
  • 2018
  • Ingår i: Consumption Markets and Culture. - 10253866 .- 1477223X.
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this paper is to describe and explain how smartphone apps,designed to assist consumers in making informed ethical choices andgreening their everyday practices, enable and shape ethical consumption.Taking a socio-material approach and drawing on an ethnographic studyof three ethical consumption apps – the Green guide, the Fair trade appand Shopgun – the paper shows that these digital devices are scripted tohybridize with consumers and facilitate key ethical consumer actions.When consumers follow the scripts of these apps, using them in everydaypractices, the apps put pressure on consumers to act “ethically” byproblematizing consumption in various ways while also, andsimultaneously, endowing them with the agential capacities required tosolve these problems. Consequently, these devices both motivateconsumers and enable ethical consumption, producing, under the rightconditions, capable and self-reflexive ethical consumer hybrids.
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